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Evaluation of pain following ozonated chlorhexidine and octinidine irrigation in endodontic retreatment.

Evaluation of efficacy of ozonated and non-ozonated 2% Chlorhexidine gluconate and 0.1% Octinidine hydrochloride with and without hypochlorite application in single visit endodontic retreatment: A randomised clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/040315
Enrollment
120
Registered
2022-02-15
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: 2% Chlorhexidine: Ozonated 2% Chlorhexidine will be used Intervention2: Ozonated 2% Chlorhexidine with sodium hypochlorite: Ozonated 2% Chlorhexidine with sodium hypochlorite applied fo

Sponsors

Pacific dental college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with single rooted, root-filled tooth with persistent apical periodontitis / symptomatic teeth with or without lesion requiring endodontic retreatment with radiographic/clinical evidence of previous endodontic treatment and periradicular disease were included in the study were recruited. Other inclusion criteria were endodontic treatment done > 3 years back, sufficient coronal tooth structure for adequate isolation with rubber dam, gutta-percha material within 4â??7 mm of the radiographic apex and no direct exposure of root canal filling material to oral cavity.

Exclusion criteria

Exclusion criteria: Medically compromised patients, patients allergic to the local anesthetic agent/ irrigants/ ozone and patients with recent myocardial infarction, acute alcohol intoxication, active bleeding, uncontrolled hyperthyroidism, thrombocytopenia, glucose 6 phosphatase deficiency (contraindications of ozone therapy) were excluded. Patients under 18 years of age, with swelling and/or acute apical abscess; analgesic/ antibiotic/ corticosteroid / anti-inflammatory taken within the past 7 days before treatment, and multiple teeth (to eliminate the possibility of pain referral), periodontal pocket deeper than 4 mm, intraradicular posts were excluded.

Design outcomes

Primary

MeasureTime frame
Pain after secondary endodontic treatmentTimepoint: At baseline, after 6, 12, 24, 48 hours, and 7 days—

Secondary

MeasureTime frame
Pain after secondary endodontic treatmentTimepoint: At baseline, after 6, 12, 24, 48 hours, and 7 days—

Countries

India

Contacts

Public ContactNidhi Sinha

PACIFIC DENTAL COLLEGE AND HOSPITAL

dr.nidhi.sinha@gmail.com08619423478

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026