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Before surgery intranasal dexmedetomidine administration and it’s effect on spinal anaesthesia in leg orthopaedic surgeries

Effect of pre operative intranasal dexmedetomidine on characteristics of spinal anesthesia with hyperbaric bupivacaine for lower limb orthopaedic surgeries- a double blinded randomised control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/040313
Enrollment
60
Registered
2022-02-15
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intranasal dexmedetomdine: Intranasal dexmedetomidine is administered pre operatively 20mins prior to spinal anaesthesia in lower limb orthopaedic surgeries followed up for 6 hours Cont

Sponsors

AIIMS RAIPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years Study includes both male and female All orthopedic surgeries under spinal anesthesia Signed informed consent given by legally authorized representative ASA Grade 1 and 2

Exclusion criteria

Exclusion criteria: Non-compliant Patients Allergy to the drug Patients on Beta blockers or Anti-hypertensive drugs Recent history of use of other sedatives and anxiolytics Patients on antidepressants Recent history of upper respiratory tract infection/ history of bronchial asthma Presence of obvious nasal mass

Design outcomes

Primary

MeasureTime frame
Potentiation of spinal effect with intranasal dexmedetomidine. Improved analgesia effect with intranasal dexmedetomidine. Satisfactory sedation. Reduced need of Opioids in the post operative period. Timepoint: Six hours—

Secondary

MeasureTime frame
1. To assess the effect of pre operative intranasal dexmedetomidine in causing intraoperative and postoperative analgesia. 2. To assess the effect of pre operative intranasal dexmedetomidine as sedative intraoperatively/post-operatively by RASS scale. 3. To look for any adverse effects following intranasal administration of the drug. 4. The need for rescue analgesia Timepoint: 6 hours—

Countries

India

Contacts

Public ContactDr Jitendra Kalbande

All India Institute of Medical Sciences, Raipur

drjitu222@gmail.com9096447683

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026