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Comparison of Use of two drugs taken through nose via special device before operation (nebulisation) for prevention of sorethroat which may occur in postoperative period due to insertion of a tube in windpipe.

Preoperative nebulization with Magnesium sulfate versus Ketamine for prevention of endotracheal tube induced postoperative sore throat-A prospective,randomized,comparative clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/040289
Enrollment
144
Registered
2022-02-14
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs

Interventions

Intervention1: ketamine: Patients nebulised with Ketamine 50 mg(1 ml) in 4ml of normal saline over 15-20 minutes once before induction on the day of surgery Intervention2: Magnesium sulfate: Patient

Sponsors

SSG Hospital Vadodara
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients posted for elective surgery under General anaesthesia requiring intubation and expected to last for less than three hours 2.ASA status I, II,III 3.Mallampatti airway assessment of Grade I and II.

Exclusion criteria

Exclusion criteria: 1)Patients who refuse to give consent 2)Anticipated difficult airway or Mallampatti Grade III & IV 3)Preoperative sore throat. 4)Active upper respiratory tract infections 5)Procedures requiring perioperative nasogastric tube placement or throat packing. 6)Patients with a high risk of aspiration. 7)Surgery involving oral cavity,nasopharynx, larynx or neck region 8)History of allergies/ bronchial asthma/ Chronic obstructive pulmonary disease 9)Surgery in prone position 10)Pregnant women.

Design outcomes

Primary

MeasureTime frame
To compare the incidence and severity of sorethroat at 4th postoperative hour.Timepoint: 4th postoperative hour.

Secondary

MeasureTime frame
1) To compare the incidence and severity of sorethroat at 0, 2nd,6th,12th and 24th postoperative hours 2) To compare the incidence and severity of postoperative hoarseness of voice and cough 3) To note any side effects like nausea,vomitting and dry mouth Timepoint: 0,2,6,12 and 24 hours

Countries

India

Contacts

Public ContactDr Priyankaben Patel

Govt Medical College,SSG Hospital,Vadodara

dr.darshna1968@yahoo.com9925013155

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026