Health Condition 1: - Health Condition 2: O- Medical and Surgical Health Condition 3: 8- Other Procedures
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Dr Oinam Monica Devi
Design Innovation Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patients presenting with clinical evidence of Cyclosporine-induced gingival overgrowth. Systemically healthy patients who are not under Cyclosporine medication but require routine gingival excisional procedures like crown lengthening and gingivoplasty
Exclusion criteria
Exclusion criteria: Patients with history of: 1.Pregnancy,lactation,smoking 2.Long-induced administration of anti-inflammatory medication 3.Excessive consumption of alcohol 4.Localized radiation therapy of the oral cavity 5.Have undergone periodontal therapy within the preceding 6 months 6.Patient not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Total macrophages in the tissue sample using IHC CD68 marker. 2. Count of M1 and M2 macrophages using IHC markers CD80,CD86,CD163,CD206 3.Relative ratio of M1 and M2 macrophages in both test and control groups. 4.To evaluate histogically the severity of inflammation in tissue samples and correlate it with the relative ratio of M1 and M2 subsets of macrophagesTimepoint: 1 week | — |
Secondary
| Measure | Time frame |
|---|---|
| Periodontal parameters such as bleeding index, probing depth, clinical attachment lossTimepoint: 1 week | — |
Countries
India
Contacts
Public ContactDr Nandini Bhaskar
Dr Harvansh Singh Judge Institute of Dental Sciences and hospital
Outcome results
None listed