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Comparison of sildenafil and estrogen for improvement of uterine health in patients with infertility

Comparative effectiveness of Vaginal sildenafil And Oral estradiol Valerate on endometrial thickening in infertility patients ââ?¬â?? A Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/040244
Enrollment
50
Registered
2022-02-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N972- Female infertility of uterine origin

Interventions

Intervention1: Effervescent vaginal sildenafil: Effervescent vaginal sildenafil 25mg ,6 hourly for 5days for endometrial thickness in infertility patients Control Intervention1: Estradiol valerate: 2m

Sponsors

SRM College Of Pharmacy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Primary and secondary infertility. Endometrial lining thickness <7mm in pre-ovulatory phase of menstrual cycle.

Exclusion criteria

Exclusion criteria: Women with major health problems (i.e.cardiovascular disease,endocrine abnormalities,Renal and liver disease, patients with history of seizures . Uterine structural anomalies and other pathologies such as endometrial polyps,severe intrauterine adhesion,hydrosalpinx or pyosalpinx.

Design outcomes

Primary

MeasureTime frame
To compare the improvement in endometrial thickness between vaginal sildenafil and oral estradiol valerate in patients with infertility.Timepoint: Baseline ET,5days—

Secondary

MeasureTime frame
To compare the improvement of endometrial vascularity between vaginal sildenafil and oral estradiol valerate. To compare the pregnancy rate outcomes among patients treated with vaginal sildenafil and oral estradiol valerate.Timepoint: Baseline PI,5Days Baseline pregnancy rate ,4weeks—

Countries

India

Contacts

Public ContactDr JAGADEESAN M

SRM Institute of science and technology ,kattankulathur.

ms8744@srmist.edu.in9677552280

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026