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Aggressive versus conservative endoscopic therapy for gastric varices

A Prospective, Single-centre, Randomized, Open-Label Study to Investigate the efficacy and long-term outcome of cyanoacrylate glue for obliteration of all gastric varices (GOV1, GOV2, IGV1, IGV2) versus obliteration of gastric varices with SRH in cirrhotic patients presenting with first episode of variceal bleed

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/040188
Enrollment
145
Registered
2022-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K746- Other and unspecified cirrhosis ofliver

Interventions

Intervention1: Group A: endoscopic cyanoacrylate (CYA) injection for all visible GOV1, GOV2 and IGV1, IGV2 and EVL for esophageal varices. Control Intervention1: Group B: EVL for esophageal varices,

Sponsors

Surat Institute of Digestive Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of cirrhosis with acute variceal bleed

Exclusion criteria

Exclusion criteria: 1) Non cirrhotic portal hypertension 2) Patients with IGV2 3) Only esophageal varices, no gastric varices 4) Past history of variceal bleed 5) Past endotherapy as primary prophylaxis 6) Contraindications to beta blockers and cyanoacrylate injection 7) Pregnancy

Design outcomes

Primary

MeasureTime frame
Variceal rebleed or death during 1 year follow upTimepoint: 1 year—

Secondary

MeasureTime frame
1. Increase or decrease in size of esophageal and gastric varices. 2. Appearance of new esophageal and gastric varices. 3. Appearance or worsening of portal hypertensive gastropathy. 4. Development of new complications like Hepatic encephalopathy, Hepatorenal syndrome, Sepsis, Ascites/Refractory ascites, Spontaneous bacterial peritonitis, Hepatopulmonary syndrome, Hepatocellular carcinoma. Timepoint: 1 year—

Countries

India

Contacts

Public ContactRitesh Prajapati

Surat Institute of Digestive Sciences

riteshprajapati87@gmail.com8373925671

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026