Health Condition 1: C713- Malignant neoplasm of parietal lobe Health Condition 2: C713- Malignant neoplasm of parietal lobe Health Condition 3: C712- Malignant neoplasm of temporal lobe
Conditions
Interventions
Intervention1: Propofol: GABA agonist -anesthetic drug used for sedating patient to Observer Assessment Sedation score (OASS) of 4 and to observe changes in NIHSS and SSEP.Dose administered via targe
Sponsors
Sree Chitra Tirunal institute of Medical sciences and technology
Eligibility
Inclusion criteria
Inclusion criteria: Patients posted for elective supratentorial high-grade gliomas resection surgeries. 1)Age18-65years. 2)ASA grade I and II . 3)No pre operative sensory or motor neurological deficits. 4) Glasgow coma scalescore 14-15.
Exclusion criteria
Exclusion criteria: Patient refusal for study . 1)Patients with focal neurological deficits. 2)GCS score less than 14 3)Age less than 18 years and more than 60 years . 4)ASA grade III and IV . 5) Pregnant or lactating women. 6) Recurrent brain tumor. 7) Unable to communicate, comprehend or co operate during a neurological examination. 8)Impaired mental status 9) Presence of significant comorbidities like coronary artery disease, COPD, systemic hypertension, chronic renal disease. 10) Drug intake like sedatives/drugs/alcohol use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Change in NIHSS scoring 2 from baseline. 2) Change in amplitude /latency in recording ssep of upper limbs.Timepoint: 1) Change in NIHSS scoring 2 from baseline. 2) Change in amplitude /latency in recording ssep of upper limbs. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation with post op neurological deficitsTimepoint: NIHSS score recorded 3 hours following surgery | — |
Countries
India
Contacts
Public ContactDr Manikandan S
SCTIMST,TRIVANDRUM
Outcome results
None listed