Comparison of two drugs levosimendan and milrinone for better outcome of coronary artery bypass grafting surgery

Effects of levosimendan or milrinone on left atrial pressure in patients undergoing off-pump coronary artery bypass grafting: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/02/040134

Enrollment

Registered

2022-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: INJ. LEVOSIMENDAN: 0.1Î¼g/kg/min starting after induction for the entire intraoperative period.WILL EVALUATE EFFECT ON LEFT ATRIAL PRESSURE IN OPCAB SURGERY Control Intervention1: MILRI

Eligibility

Inclusion criteria

Inclusion criteria: Triple vessel disease fulfilling the criteria for OPCAB Ejection fraction (EF) 35-55%

Exclusion criteria

Exclusion criteria: I. Patientâ??s refusal ii. Known allergy to any of the drug iii. NYHA Grade 4 iv. Presence of haemodynamically significant arrhythmia v. Left main coronary artery involvement vi. Presence of hepatic / renal disease vii. Presence of neurological disease

Design outcomes

Primary

Measure	Time frame
Pulmonary capillary wedge pressure (PCWP) or Pulmonary artery occlusion pressure (PAOP)Timepoint: BASELINE	—

Secondary

Measure	Time frame
Haemodynamic parameters: a. Heart rate b. Arterial Blood Pressure (systolic, diastolic and mean) c. Pulmonary Artery Pressure (systolic, diastolic and mean) d. Total inotrope requirement 2. Transoesophageal echocardiographic parameters: a. PV S wave b. PV D wave c. PV A wave d. PV DTD e. PV S/D f. MV E wave g. MV A wave h. MV E/A i. MV eâ?? j. MV aâ?? k. MV E/eâ?? Laboratory parameters: a. pH, b. pO2, c. pCO2, d. HCO3-, e. Base DeficitTimepoint: INTRAOPERATIVE	—

Measure

Time frame

Haemodynamic parameters: a. Heart rate b. Arterial Blood Pressure (systolic, diastolic and mean) c. Pulmonary Artery Pressure (systolic, diastolic and mean) d. Total inotrope requirement 2. Transoesophageal echocardiographic parameters: a. PV S wave b. PV D wave c. PV A wave d. PV DTD e. PV S/D f. MV E wave g. MV A wave h. MV E/A i. MV eâ?? j. MV aâ?? k. MV E/eâ?? Laboratory parameters: a. pH, b. pO2, c. pCO2, d. HCO3-, e. Base DeficitTimepoint: INTRAOPERATIVE

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Countries

India

Contacts

Public ContactABHINANDAN MONDAL

IPGME&R and SSKM Hospital

gkakali354@gmail.com8697638105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026