Health Condition 1: S06- Intracranial injury
Conditions
Interventions
None listed
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age >18 and 2. Severe TBI patients requiring MV > 24 h
Exclusion criteria
Exclusion criteria: 1. Patients with cardiac arrhythmias/ severe cardiac disease 2. Patients with neuromuscular disorders 3. Patients with spinal shock 4. Patients on beta-blockers / antiarrhythmic drugs / anticholinergic drugs 5. Patients with major cognitive impairment (malignant stroke, post-cardiac arrest) 6. Patients with GCS 3 7. Pregnancy 8. Refusal to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of pain by ANI and its comparison with the Critical Pain Observation Tool-Neuro in severe TBI patientsTimepoint: Pain assessment will be done once a day, pre and post stimulus, on day 2 and day 4 of ICU admission | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlate nociceptive levels (ANI) with the level of consciousness (using Patient State Index/BIS/Entropy). 2. Correlate nociceptive levels (ANI) with the level of autonomic dysfunction (using Heart Rate variability). Timepoint: Correlation will be done using data collected on day 2 and day 4 of ICU admission | — |
Countries
India
Contacts
Public ContactTEJASWI GM
NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES
Outcome results
None listed