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Assessing Potential Drug- Drug Interactions with Integrase Inhibitors in HIV patients.

Assessment of Potential Drug-Drug Interactions (PDDIs) with Integrase Strand Transfer Inhibitors (INSTI)-based Antiretroviral Therapy (ART) in People Living with HIV (PLWHIV): A cross-sectional study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/02/040013
Enrollment
240
Registered
2022-02-03
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B20- Human immunodeficiency virus [HIV]disease

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Manipal Academy of Higher Education
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: HIV seropositive patients (HIV-SPP) of either sex on INSTI-based and other ART therapies, from both in-patient and out-patient departments of the study center.

Exclusion criteria

Exclusion criteria: 1. HIV-SPP who refused ART treatment and did not consent to participate in the study. 2. HIV-SPP taking only herbal medicines and medications belonging to Ayurvedic, Homeopathic, Siddha, and Unani treatments.

Design outcomes

Primary

MeasureTime frame
The identification, assessment, and documentation of all PDDIs within INSTI-based ART therapy and between ART and other therapies in HIV patients. To establish the reduced incidence of DDIs in the INSTI-based ART regimens, compared to other ART regimens. To report the Incidence and Prevalence rates of the established PDDIs, their mechanism(s), and outline the management.Timepoint: Patient files will be screened at the Baseline.

Secondary

MeasureTime frame
To report the Incidence and Prevalence rates of the established PDDIs, their mechanism(s), and outline the management.Timepoint: Patient files will be screened at the Baseline.

Countries

India

Contacts

Public ContactAieshel Serafin Johnson

Department of Pharmacy Practice, Manipal College of Pharmacy Practice

rajesh.r@manipal.edu9448374166

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026