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A study to compare different intravenous fluids on certain blood parameters during the surgery in patients undergoing elective surgery for brain tumors

A comparative study to assess the effect of intravenous use of normal saline, balanced salt solution (plasmalyte), and combination of normal saline and Ringer�s lactate on intraoperative acid-base parameters & serum osmolality in patients undergoing elective craniotomy for brain tumors: A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/039979
Enrollment
75
Registered
2022-02-03
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Normal saline and Ringer�s lactate: Patients who would receive combination of normal saline and Ringer�s lactate as i.v maintenance fluid during the intraoperative period

Sponsors

Dr Abinaya Prakashbabu U
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA PS class I & II Patients undergoing resection of supratentorial & infratentorial brain tumours

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Pregnant patients 3. Lactating patients 4. Patients with renal, hepatic or cardiac insufficiency, or any endocrinological dysfunction 5. Patients with GCS � 13 6. Patients undergoing second neurosurgical procedure

Design outcomes

Primary

MeasureTime frame
1. ABG analysis to measure the acid-base parameters: pH, HCOââ??Æ?â?», Clâ?» 2. Serum osmolality, sodium, potassium, calcium, hematocritTimepoint: Preinduction (baseline), at the time of skin incision, at bone flap elevation, at tumour resection, at skin closure, during emergence from anesthesia—

Secondary

MeasureTime frame
1. Brain relaxation score 2. Hemodynamic parametersTimepoint: 1. At bone flap elevation, tumor resection and at closure 2. Baseline (preinduction), Continually every 15min-30min—

Countries

India

Contacts

Public ContactAbinaya Prakashbabu U

AIIMS, Raipur

monicakhetrapal@yahoo.com8608289662

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026