To control intraoperative blood pressure and heart rate changes

A prospective, randomised study to assess the haemodynamic changes in patient undergoing laparoscopic cholecystectomy under general anaesthesia with transversus abdominis plane block while creating pneumoperitoneum

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/01/039834

Enrollment

Registered

2022-01-31

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Bupivacaine 0.25%: Effect of 20 ml of 0.25% Bupivacaine, bilateral Transversus abdominis plane block for 12 hrs Control Intervention1: Normal saline 0.9%: Effect of 20 ml of 0.9% Normal

Eligibility

Inclusion criteria

Inclusion criteria: Patient posted for laparoscopic cholecystectomy of ASA 1 and 2 status between the age of 18 to 60 years not on anticoagulant or antiplatelet drug

Exclusion criteria

Exclusion criteria: Patient not willing to consent, history of allergy to study drug, having coagulation disorder or uncontrolled hypertension.

Design outcomes

Primary

Measure	Time frame
To compare whether bilateral Transversus abdominis plane block with 0.25% bupivacaine given in the study group just after induction can alleviate haemodynamic changes in laparoscopic cholecystectomy while creating pneumoperitoneum with control group who are receiving 0.9% normal saline in Transversus abdominis plane blockTimepoint: Before induction, just before pneumoperitoneum, immediately after pneumoperitoneum, 5 minutes 10 minutes 15 minutes 20 minutes 25 minutes 30 minutes	—

Measure

Time frame

To compare whether bilateral Transversus abdominis plane block with 0.25% bupivacaine given in the study group just after induction can alleviate haemodynamic changes in laparoscopic cholecystectomy while creating pneumoperitoneum with control group who are receiving 0.9% normal saline in Transversus abdominis plane blockTimepoint: Before induction, just before pneumoperitoneum, immediately after pneumoperitoneum, 5 minutes 10 minutes 15 minutes 20 minutes 25 minutes 30 minutes

—

Secondary

Measure	Time frame
To observe analgesia in post laparoscopic cholecystectomy patients using visual analogue scale in both groupTimepoint: 1 hour 4 hour 8 hour 12 hour	—

Countries

India

Contacts

Public ContactDr Ekramul Haque

Rajendra Institute of Medical Sciences

deekshanegi94@gmail.com7016368230

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026