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Evaluation of effect of vitamin C and vitamin E on clinical outcomes in paraquat poisoning patients on supportive treatment

A PROSPECTIVE RANDOMIZED STUDY TO EVALUATE THE COMBINED EFFECT OF INJECTION VITAMIN C AND ORAL VITAMIN E ON CLINICAL OUTCOMES AND OXIDATIVE STRESS MARKERS IN PARAQUAT POISONING PATIENTS ON SUPPORTIVE TREATMENT AT A TERTIARY CARE HOSPITAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/01/039800
Enrollment
50
Registered
2022-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T658- Toxic effect of other specified substances

Interventions

Intervention1: Vitamin C, Vitamin E: In one arm patients will receive injection vitamin C 2000 mg intravenously twice daily and capsule vitamin E 400 mg orally twice daily for two weeks along with bac

Sponsors

Dr Vuppalanchi Bhavani
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with a known history of paraquat poisoning Patients willing to give informed consent and agree to comply with the study procedures

Exclusion criteria

Exclusion criteria: Patients with known hypersensitivity to the study medication

Design outcomes

Primary

MeasureTime frame
MortalityTimepoint: 7 days 14 days 28 days—

Secondary

MeasureTime frame
Change in MDA, GSH, NO from base line to 28 days Change in LFT, RFT from baseline to 28 days Adverse eventsTimepoint: 28 days—

Countries

India

Contacts

Public ContactDr Vuppalanchi Bhavani

Nizams Institute of Medical Sciences

ushapingali@yahoo.com9849574143

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026