Health Condition 1: C00-D49- Neoplasms
Conditions
Interventions
Intervention1: OLANZAPINE: OLANZAPINE 5MG DAILY BEFORE RADIATION
Intervention2: Olanzapine: Olanzapine 5mg daily before radiation
Control Intervention1: Placebo: Placebo before Radiation
Sponsors
Indian Council of Medical Research
Meenu Vijayan
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18 years or older Radiotherapy naive patients Patients receiving abdominal or pelvic radiotherapy Patients or their care givers willing to provide informed signed consent
Exclusion criteria
Exclusion criteria: Patients who received less than 15 fractions of radiation therapy Patients with history of brain metastasis & seizure disorder Patients receiving antipsychotic drugs within a window period of 30 days prior radiation therapy Elderly patients with dementia-related psychosis . Patients with uncontrolled diabetes mellitus Patients with drug abuse Allergic to any of the study medications Patients already on systemic corticosteroids Vomiting within the last 24hrs, prior to radiotherapy Previous history of nausea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete control of emesis (No emesis and no rescue therapy during the entire study period)Timepoint: Baseline to end of radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete control of nausea (No nausea and no rescue therapy during the entire study period)Timepoint: Baseline to end of radiotherapy | — |
Countries
India
Contacts
Public ContactMeenu Vijayan
Amrita Institute of Medical Sciences
Outcome results
None listed