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To study the role of Glycopyrrolate in prevention of fall in blood pressure caused by spinal anaesthesia during surgery in elderly patients.

Evaluation of Role of Pre-Emptive Intramuscular Glycopyrrolate in Prevention of Spinal Anaesthesia Induced Hypotension in Elderly Patients; a Randomized Controlled Interventional Study at SMS Medical College during 2021-2023.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/01/039715
Enrollment
102
Registered
2022-01-25
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection Glycopyrrolate 0.2mg: Intramuscular Injection Glycopyrrolate 0.2mg (1ml) 5 minutes prior to Sub-Arachnoid Block. Control Intervention1: Injection 0.9% Normal Saline: Intramusc

Sponsors

Department Of Anaesthesiology Sawai Man Singh Medical College And Attached Hospitals Jaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient undergoing infraumbilical or lower limb surgery under spinal anaesthesia. 2. Patients willing to give written and informed consent to participate in study. 3. Patient age equal to or more than 60 years. 4. Duration of surgery 5. Patients belonging to ASA Grade I and Grade II.

Exclusion criteria

Exclusion criteria: 1. H/O allergic reactions to local anaesthetic drugs. 2. Patient with gross spinal deformities. 3. Patient with any bleeding disorder or on anticoagulants. 4. Patient with any cardiovascular disease (Arrhythmias,heart blocks,bradycardia). 5. Patient with local infection at the injection site. 6. Patient with any hepatic or renal disease. 7. Patient with any neurological and musculoskeletal disease.

Design outcomes

Primary

MeasureTime frame
1.To determine if prophylactic intramuscular glycopyrrolate administration reduces the incidence and severity of hypotension associated with spinal anaesthesia in elderly patients. 2. To determine the difference in proportion of cases who develop hypotension after spinal anaesthesia between two groups.Timepoint: 24 hrs—

Secondary

MeasureTime frame
1. To determine the difference in hemodynamic variables (Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure) from baseline to different time intervals post the subarachnoid block between two groups. 2. To determine the difference in total dose of rescue vasopressor used between study groups.Timepoint: 24hrs—

Countries

India

Contacts

Public ContactDr PRAKYATH SHETTY

Sawai Man Singh Medical College And Attached Hospitals

drmamtasharma@hotmail.com9829566077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026