Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Oral midodrine on incidence of hypotension after subarachnoid block in lower abdominal surgery: Oral 5 mg tablet of midodrine with small sips of water one hour before subarachnoid block
Sponsors
Institute Medical Sciences Banaras Hindu University Varanasi
Eligibility
Inclusion criteria
Inclusion criteria: 1-Patients belonging to American Society of Anaesthesiologists (ASA) classification I & II status.2-Patients undergoing for elective lower abdominal surgery.
Exclusion criteria
Exclusion criteria: 1- Patient refusal 2-Patient having contraindication of Midodrine:- (a)Pheochromocytoma (b) Hypersensitivity to drug (c) severe heart disease (d) Hyperthyroidism (e) Uncontrolled hypertension (f) Increased intracranial tension (g) acute renal disease (h) Hepatic impairment 3-Elderly population or pediatric population 4-During pregnancy and breast feeding 5-Patient having contraindication of subarachnoid block
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative Hypotension ( change in systolic blood pressure and diastolic blood pressure)Timepoint: Time from administration of drug or placebo to the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1-change in Mean arterial blood pressure 2-Change in Heart Rate 3-Requirements of Mephentermine and Atropine 4-Incidence of adverse effects (time frame: up to 24 hours surgery)Timepoint: Before the administration of drug and intra-operative at every 3 minute interval for 15 minutes then at every 5 minute interval for 30 minutes then at every 10 minutes interval up to 60 minutes then at every 15 minutes till the end of surgery | — |
Countries
India
Contacts
Public ContactDr S K Mathur
Institute of Medical sciences,Banaras Hindu University,Varanasi
Outcome results
None listed