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Non-hepatic hyperammonemia(increased ammonia levels in blood in patients without any underlying liver disease) in very sick patients in ICUâ?? to see the incidence for such findings, risk factors for such high ammonia levels and effect on outcome of patient.

Non-hepatic hyperammonemia in critically ill patientsâ?? incidence, risk factors and effect on outcome

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/01/039699
Enrollment
70
Registered
2022-01-25
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R69- Illness, unspecified Health Condition 2: O- Medical and Surgical

Interventions

None listed

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient admitted in ICU during the study period 2. Age more than 18 years 3. Expected ICU stay > 24 h

Exclusion criteria

Exclusion criteria: •Denial to participate in study •Patients with acute and chronic liver diseases, including hepatitis, hepatic cirrhosis, hepatic encephalopathy, hepatorenal syndrome, hepatic injury, or other chronic liver disease •Death within the first 24 h of admission •Discharged from the ICU within 48 h of elective surgery

Design outcomes

Primary

MeasureTime frame
To evaluate the incidence of Non-Hepatic Hyperammonemia (NHH) in a mixed cohort of medical, surgical and trauma patients admitted in the adult intensive care unit.Timepoint: at admission to ICU—

Secondary

MeasureTime frame
Correlation of NHH with 1. Disease severity at admission (APACHE II and SOFA) 2. GCS 3. DeliriumTimepoint: at admission to ICU;Effect of NHH on clinical outcomes 1. Vasopressor requirement 2. Ventilation free days 3. Length of stay in the ICU 4. Mortality (in ICU, at 28 days, In hospital)Timepoint: at 28 days, death, discharge from ICU;Identification of risk factors for NHHTimepoint: at admission—

Countries

India

Contacts

Public ContactSudhir Kumar Bisherwal

AIIMS

vimirewari@gmail.com9818304880

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026