Health Condition 1: G460- Middle cerebral artery syndrome
Conditions
Interventions
Intervention1: Melatonin: Dose 20mg, Frequency HS once in night, route oral administration and duration 6 weeks.
Control Intervention1: Nil: Nil
Sponsors
Prerak Kumar
Eligibility
Inclusion criteria
Inclusion criteria: Above 55 years of age. Patient who will give consent, evidenced by signature on informed consent form, in case of illiterate subjects by thumb impression. Diagnosed case of acute ischemic stroke involving middle cerebral artery territory diagnosed by neuroimaging scan (CT Scan head :assessed by ASPECTS score). mild( 0-4)and moderate (5-14) severity as per National Institute Health Stroke Scale
Exclusion criteria
Exclusion criteria: Not give consent Age below 55 years Comorbid medical illness Hemorrhagic stroke Use of steroids, psychotropics Delirium or Dementia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of melatonin on depressive symptoms and on subjective parameters sleep. Tools: Hamilton Depression Rating scale ( depression) Pittsburgh Sleep Quality Index ( sleep quality), Hindi Mental status exam( Cognition) Modified Rankin scale ( Stroke physical recovery) National Institutes of Health Stroke Scale ( severity of stroke).Timepoint: Week 3rd and week 6th after baseline assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the effect of melatonin on physical recovery in older adults with acute ischemic stroke To assess the neurogenesis and anti-inflammatory effect of melatonin in older adults with acute ischemic stroke Timepoint: Day 7, Day 21 and Day 42. | — |
Countries
India
Contacts
Public ContactPrerak Kumar
King George’s Medical University
Outcome results
None listed