Health Condition 1: T603- Toxic effect of herbicides and fungicides
Conditions
Interventions
None listed
Sponsors
Dr TMA Pai Fellowship
Eligibility
Inclusion criteria
Inclusion criteria: Objective 1 and 2: Inclusion criteria: Patients who arrive at the Emergency ward with paraquat poisoning (confirmed by a qualitative test) within 24 hours of exposure. Patients will be included above 18 years of age, irrespective of gender, time from exposure, route of exposure (oral, inhalational or direct contact) and type of exposure (suicidal or accidental). Objective 3: Inclusion criteria: Patients enrolled in Objective 1 and 2 and expired during hospital stay who are sent for routine post-mortem examination.
Exclusion criteria
Exclusion criteria: Objective 1 and 2: Pregnant or lactating patients; patients with critical illness(es) such as cancer, patients having history of organ transplantation, patients who are already on immunosuppressants for specific medical conditions, patients exposed to paraquat with other toxic agents, patients referred from primary care and other facilities (after 24 hours of exposure), patients with incomplete data, patients lost to follow-up and patients/relatives/guardians who refuse to consent. Objective 3: Relatives/guardian who refuse consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective 1: Mortality rate within 90 days following paraquat poisoning, including 7-, 28- and 90- day mortality in each treatment group. Objective 2: Concentration of plasma paraquat at baseline (after admission), 24 hr, 48 hr and 72 hr with respect to treatment strategies. Objective 3: Gross pathology of heart and lung and histopathology of different organ tissues in death cases of acute paraquat poisoning with respect to blood level of paraquat Timepoint: Objective 1: 7-day, 28-day and 90- day mortality. Objective 2: Blood collection at baseline (after admission), 24 hr, 48 hr and 72 hr after admission. | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective 1: Assessment of prognostic factors of mortality and severity, values of laboratory investigations when performed at different intervals; days of hospitalization; the number of days in the intensive care unit; number of days with mechanical ventilation, the Acute Physiology and Chronic Health Evaluation (APACHE) II scores; sequential organ failure assessment (SOFA) scores; the frequency of ECR; adverse events and development of complications. A subgroup analysis of ECR technique with respect to 7-day, 28-day and 90- day mortality. Objective 2: Assessment of plasma levels with severity of PQ poisoning (SIPP), complications and progression of poisoning in each followed patient and results of genetic analysis. Objective 3: Correlate the findings of extent/type of damage and histopathological lesions with plasma paraquat levels. Timepoint: Objective 1: 7-day, 28-day and 90- day mortality. Objective 2: At baseline (after admission), 24 hr, 48 hr and 72 hr after admission. | — |
Countries
India
Contacts
Public ContactDr Girish Thunga
Manipal College of Pharmaceutical Sciences
Outcome results
None listed