Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue
Conditions
Interventions
None listed
Sponsors
Dioraphte
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients: Aged > 6 months old with clinically suspected Scabies. Inclusion criteria for controls: Healthy volunteers with no scabies or history of scabies and > 18 years of age
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients and controls: unclear diagnosis, other skin parasites, other skin condition, history of chronic dermatologic disease, treatment for scabies within 7 days, antibiotic treatment within the last month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The results generated will determine the diversity and dynamics of microbes associated with human scabies at a range of geographical and economical settings, which will result in the first comprehensive global snapshot of this disease complex. Longitudinal data across multiple time points through treatment will inform about treatment efficiency and provide insights into correlation-versus- causation questions. Through in depth transcriptomics/proteomics we hope to identify the molecular mechanisms underpinning the synergy between mites and bacteria, and how they work together to deal with the host defence. In summary, this project will provide baseline molecular data for translational research into improved treatment and management strategies, to ultimately better scabies disease outcomes globally.Timepoint: 4 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Longitudinal data across multiple time points through treatment will inform about treatment efficiency and provide insights into correlation-versus- causation questions. Through in depth transcriptomics/proteomics we hope to identify the molecular mechanisms underpinning the synergy between mites and bacteria, and how they work together to deal with the host defence. In summary, this project will provide baseline molecular data for translational research into improved treatment and management strategies, to ultimately better scabies disease outcomes globally.Timepoint: 4 years | — |
Countries
Australia, France, India
Contacts
Public ContactDr Pallavi Surase
Seth GS Medical college and KEM Hospital
Outcome results
None listed