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Ketofol or Propofol, agent maintaining better haemodynamics in patients undergoing trans-sphenoidal pituitary surgery under total intravenous anaesthesia.

A randomized control trial to evaluate the effects of Ketofol and Propofol on cerebral oxygenation in patients undergoing trans-sphenoidal pituitary surgery under total intravenous anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/01/039533
Enrollment
50
Registered
2022-01-18
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D337- Benign neoplasm of other specifiedparts of central nervous system Health Condition 2: G938- Other specified disorders of brain

Interventions

Intervention1: ketofol: intravenous ketofol at rate of 2ml/kg, at induction & continuous infusion throughout surgery Intervention2: Comparison of induction and maintenance anaesthetic agents: Comparis

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1, 2 Planned for elective endoscopic TNTS Pituitary Surgery

Exclusion criteria

Exclusion criteria: Consent not given Patients with history of previous pituitary surgery Patients with psychiatric disorder History of drug abuse Poorly controlled hypertension Ischaemic heart disease, valvular heart disease History of lung diseases-COPD, Asthma History of Renal diseases History of liver diseases Pituitary apoplexy Morbidly obese ( BMI >40) Pregnant patients History of allergy to any of the planned anaesthetic medications of the study

Design outcomes

Primary

MeasureTime frame
To compare effects of ketofol versus propofol on cerebral oxygenation (rSO2) in patients undergoing TNTS Pituitary surgeryTimepoint: Baseline then Every 30min interval—

Secondary

MeasureTime frame
To compare between both drugs intraoperative haemodynamic parameters ( HR, MAP), intraoperative requirements of propofol and opioids, postoperative emergenceTimepoint: Baseline & every 30min—

Countries

India

Contacts

Public ContactDr Sudeshna Padhi

AIIMS, New Delhi

c.arvind61@yahoo.in9871045824

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026