To decrease the pain during induction of general anaesthesia using Propofol (Induction agent) injection in operation theatre.

Comparison of intravenous Ondansetron vs Dexamethasone as pre-treatment drugs to prevent Propofol induced pain in patients undergoing laparoscopic cholecystectomy: A randomised controlled study.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/01/039506

Enrollment

Registered

2022-01-18

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexamethasone: Effect of 8mg of Intravenous Dexamethasone for 12hrs. Control Intervention1: Ondansetron: Effect of 8mg of Intravenous Ondansetron for 12hrs

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are posted for laparoscopic cholecystectomy of ASA 1 & 2 status between the age of 20-70 years.

Exclusion criteria

Exclusion criteria: Patients not willing to consent, history of hypersensitivity to drug, past history of burn injuries/chemotherapy/radiotherapy, laparoscopic surgeries converted to open surgeries, if drugs other than study drug used for alleviation of Propofol.

Design outcomes

Primary

Measure	Time frame
Comparison of intravenous Ondansetron vs Dexamethasone as pre-treatment drugs to prevent Propofol induced pain in patients undergoing laparoscopic cholecystectomy.Timepoint: 0 mins, 1st min after injection of Propofol, 3rd min after injection which is before intubation, 5th minute after injection which is after intubation.	—

Secondary

Measure	Time frame
To compare the effect of intravenous Ondansetron vs Dexamethasone as pre-treatment drugs to prevent postoperative nausea & vomiting after laparoscopic surgeries.Timepoint: Within 12 hrs	—

Countries

India

Contacts

Public ContactDr Wasimul Hoda

RIMS, Ranchi

7adit7@gmail.com8411901927

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026