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A study to compare dexmedetomidine (sedative and analgesic) and fentanyl (sedative and analgesic) on propofol (sedative and hypnotic) requirement in surgeries done under general anesthesia without muscle relaxant

Comparison of the effectiveness of intravenous dexmedetomidine versus fentanyl as an adjuvant to propofol for maintenance of entropy guided general anaesthesia in patients undergoing elective brachial plexus repair surgeries: A prospective randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/01/039438
Enrollment
50
Registered
2022-01-14
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine plus propofol (Group D): Before induction, loading dose of intravenous dexmedetomidine 1 mcg/kg will be given over 10 mins, followed by 0.5 mcg/kg/hour maintenance dose

Sponsors

Nizams Institute of Medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA class I and II, 2. Age â?? 18 to 60 years, 3. Patients of either sex, 4. Patients undergoing elective brachial plexus repair surgeries

Exclusion criteria

Exclusion criteria: 1. Patients who are not willing to participate or not co-operative 2. Pregnant or lactating women 3. ASA Grade-III and IV 4. Haemodynamic instability 5. Patients with significant hepatic, renal, cardiac, neurologic and psychiatric illness 6. Patients with history of drug sensitivity to study drugs 7. Patients with hypertriglyceridemia 8. Patients on beta-blockers, sedative drugs and analgesics 9. Pseudocholinesterase deficiency and hyperkalemia 10. Body mass index greater than or equal to 30

Design outcomes

Primary

MeasureTime frame
comparison of total propofol requirement in propofol-dexmedetomidine and propofol-fentanyl infusion groups in patients undergoing elective brachial plexus repair surgeries under general anesthesia with entropy guidanceTimepoint: Intraoperative period—

Secondary

MeasureTime frame
Comparison of intraoperative hemodynamics between two groups Comparison of Extubation Quality Score between two groups Comparison of postoperative sedation using Ramsay Sedation Scale between two groupTimepoint: Intraoperative period and postoperative period ( upto 1 hour )—

Countries

India

Contacts

Public ContactKanithi Geeta

Nizamâ??s Institute of Medical Sciences

pratyusha.1212@gmail.com9347732651

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026