Health Condition 1: K70- Alcoholic liver disease Health Condition 2: K74- Fibrosis and cirrhosis of liver Health Condition 3: K72- Hepatic failure, not elsewhere classified Health Condition 4: K76- Other diseases of liver Health Condition 5: K719- Toxic liver disease, unspecified
Conditions
Interventions
None listed
Sponsors
Institute of Liver and Biliary sciences
Eligibility
Inclusion criteria
Inclusion criteria: patients with liver disease who are expected to be invasively mechanically ventilated for more than 48 hours
Exclusion criteria
Exclusion criteria: chest trauma or chest tube at the ultrasound measurement site, prior history of neuromuscular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to define the proportion of patients developing changes in muscle thickness( diaphragm and intercostal) and the magnitude of change in thickness among mechanically ventilated patients with liver diseaseTimepoint: at baseline,3rd, 5th, 7 th day of mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| to assess predictors of change in muscle thickness over time among mechanically ventilated patients with liver disease such as ventilator mode, duration of mechanical ventilation, length of ICU stay, medications including sedatives, analgesics, catecholamines, steroids, muscle relaxants. To assess need for reintubation/tracheostomy, use of high flow nasal cannula/ non invasive ventilation post extubationTimepoint: patients would be followed from day 1 of mechanical ventilation uptil , day 3, day 5 ,day 7 till discharge from ICU. | — |
Countries
India
Contacts
Public ContactDR SHIVALI PANWAR
Institute of Liver and Biliary Sciences New Delhi
Outcome results
None listed