Health Condition 1: D899- Disorder involving the immune mechanism, unspecified
Conditions
Interventions
None listed
Sponsors
Manipal Academy of Higher Education Manipal
Eligibility
Inclusion criteria
Inclusion criteria: Group 1: 1. Adult patients (=18 years) admitted to ICU with preexisting septicaemia and sepsis 2. SOFA score =2 3. Needs vasopressor therapy to elevate mean arterial pressure =65 mmHg and lactate >2mmol/L (18mg/dL) despite adequate fluid resuscitation 4. Culture positivity for E. coli within 48 hours from the time of first blood sample drawn for culture testing Group 2: 1. Adult patients (=18 years) who were admitted to wards/ICU with preexisting bacteremia 2. SOFA score 3. Culture positivity for E. coli within 48 hours from time of first blood sample drawn for culture testing. Group 3: 1. Healthy adult volunteers (=18 years and not admitted to the hospital) or those with well-controlled underlying conditions (hypertension, diabetes etc.) 2. Able and willing to complete the informed consent process 3. Volunteer must agree to have blood stored and used for this study (within the scope of the approved duration and purposes of this study)
Exclusion criteria
Exclusion criteria: Group 1 and 2: 1. Pregnant or lactating women 2. Documented immunocompromised clinical status 3. Chronic kidney disease and/or on dialysis 4. Blood transfusion >4 units in the past week 5. Undergone surgeries, grafts, transfusions or extra-corporeal circulation in the last 6 months 6. Prolonged antibiotic usage in the last 3 months 7. History of sepsis/septic shock in the last 6 months 8. Anticipated hospitalization of =2 days 9. Second admission or transfer from other hospital ICUs or previous enrolment in the study 10. Restricted liberty or under legal protection 11. Inability to get consent Group 3: 1. Pregnant or breast-feeding 2. Infected with any infectious diseases 3. Hemophilia, severe coagulation disorders or impaired venous access 4. Prolonged antibiotic usage in the last 3 months 5. History of sepsis/septic shock in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Protein-Protein interactionsTimepoint: baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactVenkat Abhiram Earny
Kasturba Medical College, Manipal
Outcome results
None listed