Health Condition 1: S063- Focal traumatic brain injury
Conditions
Interventions
None listed
Sponsors
Department of Anaesthesia and Intensive Care
Eligibility
Inclusion criteria
Inclusion criteria: Adults between 18-65 years of age, diagnosed with isolated severe Traumatic Brain Injury (GCS
Exclusion criteria
Exclusion criteria: ââ?¬Â¢ Attendantââ?¬•s refusal to consent ââ?¬Â¢ Admission after injury past 24 hours ââ?¬Â¢ Pregnant women ââ?¬Â¢ Patients having previous history of coagulation disorder ââ?¬Â¢ Patients on anticoagulant therapy. ââ?¬Â¢ Polytrauma patients. ââ?¬Â¢ Patients receiving blood products or have received blood products in last month. ââ?¬Â¢ Patients in shock ââ?¬Â¢ Patients with septic coagulopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the incidence of abnormal SONOCLOT (SONACT, Clot rate, Platelet function, Time to peak and peak amplitude) and conventional coagulation assay (INR, aPTT ratio) values in the patients of severe TBI with different CT findings.Timepoint: Baseline determination at the time of admission After 24 hours After 48 hours Outcome after 1 month | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 To determine association of type of injury in CT with different phases of haemostasis (hypo and hyper coagulopathy) parameters provided by SONOCLOT, (as secondary outcome) 2 To observe the correlation of different type of injury in CT with hypo and hyper coagulopathy parameters provided by SONOCLOT at 0, 24 and 48 hrs 3 To evaluate the outcome of the patients who develop coagulopathy following sTBI using Glasgow outcome scale (as secondary outcome) Timepoint: 1-4 months Follow up and analysis of secondary outcome | — |
Countries
India
Contacts
Public ContactKajal Jain
PGIMER, CHANDIGARH
Outcome results
None listed