Health Condition 1: K861- Other chronic pancreatitis
Conditions
Interventions
Intervention1: Simvastatin: 40mg OD, Orally for 6 months
Control Intervention1: Placebo: 40mg OD, Orally for 6 months
Sponsors
SIDS Hospital and Research Centre
SIDS Hospital and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: At screening, Adult patients ( >18 years of age, at the time of enrollment) with chronic pancreatitis (Cambridge grade 0 to III); and women of child-bearing potential having confirmed negative pregnancy test result prior to enrollment are eligible for the study.
Exclusion criteria
Exclusion criteria: 1. If the patients had major ductal abnormalities (Cambridge Grade IV) or complications of chronic pancreatitis 2. If there will be any evidence of complete pancreas divisum either by MRCP or ERCP. 3. If there will be a history of active malignancy or pancreatic surgery or chronic myopathy 4. If patients were narcotic dependent or had previous exposure to HMG CoA inhibitor therapy 5. If the patient had family history of pancreatitis or pancreatic cancer 6. Pregnant or breast feeding women 7. If patient had any other reversible etiology such as alcohol, smoking, hypertriglyceridemia, autoimmune pancreatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the Izbicki pain scoreTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in levels of Fecal ElastaseTimepoint: 6 months;Change in pancreatitis-related hospital readmissionsTimepoint: 6 months;Change in quality of life score as measured by the QLQ-C30 and QLQ-PAN28(CP)Timepoint: 6 months;Change in serum levels of CRP, IL-6, IL-10, TGF-Ã?²1, MMP-9, TNF-Ã?±, ands-fractalkine Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactMs Archi Patel
SIDS Hospital and Research Center
Outcome results
None listed