Health Condition 1: F42- Obsessive-compulsive disorder
Conditions
Interventions
Intervention1: Ketamine infusion: This arm will receive 0.5mg/kg intravenous infusion of ketamine (on alternate days). Patients will receive 6 such infusions over the period of 2 weeks
Control Interve
Sponsors
Ahana Hospitals LLP
Eligibility
Inclusion criteria
Inclusion criteria: Participants must be willing to give a written informed consent document; Participants must fulfill DSM-5 criteria for Obsessive Compulsive Disorder, and should have been resistant to at least 2 SSRI trails of adequate dose and duration and psychotherapy. Participants must be medically and neurologically healthy.
Exclusion criteria
Exclusion criteria: Those who have neurological disorders, severe medical illness, mental retardation and co-morbid psychiatric diagnoses such as psychosis, substance dependence Women who are pregnancy or breastfeeding Those who are allergic to ketamine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures were (i) a reduction in illness severity on the YBOCS scale compared to baseline scores, and (ii) response [as defined by â?¥35 % reduction (response) and 25â??35 % reduction (partial response)] on the YBOCS total score.Timepoint: at baseline, 2 weeks, 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome measures were a reduction in depression severity on the HAM-D scale compared to baseline scores.Timepoint: at baseline, 2 weeks, 4 weeks | — |
Countries
India
Contacts
Public ContactVikhram Ramasubramanian
Ahana hospitals, LLP
Outcome results
None listed