Health Condition 1: G94- Other disorders of brain in diseases classified elsewhere
Conditions
Interventions
Intervention1: Nicorandil: Nicorandil 5mg tablet BD i.e twice a day for one month via oral route along with standard of care.
Control Intervention1: standard of care: The standard therapy for stroke
Sponsors
SRMIST
Eligibility
Inclusion criteria
Inclusion criteria: -Age 18 -75 years. -Both genders. -Diagnosis of acute ischemic stroke. -More than 24 hours of onset of symptoms and not greater than 96 hours. -Modified Rankin scale greater than two. -Ability to ingest oral medication. -BMI >18.5 kg /m².
Exclusion criteria
Exclusion criteria: Haemorrhagic stroke. Hypotension with a SBP Patients on ACEIs and ARBs. Patients on steroids. Patients with respiratory compromise. Patients on antidepressant drugs. Severe acid peptic disease. Kidney dysfunction (GFR Intake of NSAID (exemption of Paracetamol). Severe unstable medical illnesses, including uncontrolled cardiac conditions or heart failure, cardiogenic shock (New York Heart Association Class III or IV). Use of any investigational agents within 30 days prior to screening. Pregnant women and lactating mothers. Severe hypovolemia. Severe liver dysfunction. Severe bradycardia ( Patients with G6PD deficiency. Clotting factor Deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale Timepoint: 0, 30 and 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Barthel indexTimepoint: 0, 30 and 90 days | — |
Countries
India
Contacts
Public ContactDr K Subramaniyan
SRM College of Pharmacy, SRMIST
Outcome results
None listed