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Changes in blood pressure and cough reflex during tracheostomy tube change by using two different drugs.

To compare the effect of Dexmedetomidine and Fentanyl on the attenuation of airway and pressure response during tracheostomy tube change in traumatic brain injury patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/01/039224
Enrollment
100
Registered
2022-01-06
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S069- Unspecified intracranial injury

Interventions

Intervention1: Dexmedetomidine: 0.5 mcg/kg diluted in 25ml normal saline , infused over 10min before procedure Control Intervention1: Fentanyl: 1 mcg/kg diluted in 25ml normal saline over 10min before

Sponsors

Trauma Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Head injury patients on tracheostomy tube. 2.Age group between 18 and 60 years.

Exclusion criteria

Exclusion criteria: 1.Cervical spine injury. 2.Heart Rate below 60/min. 3.Arterial pressure less than 100/60 mm of Hg. 4.History of allergic reaction to the study mentioned drugs. 5.Refusal to take part in the study. 6.Patients with COPD/Asthma/Diabetes/Hypertension. 7.Patients on Neuromuscular blockers or any sedative drugs.

Design outcomes

Primary

MeasureTime frame
Hemodynamic parameters and cough reflexTimepoint: 0,1,3,5,10,15 and 30 min—

Secondary

MeasureTime frame
associated adverse eventsTimepoint: 0,1,3,5,10,15 and 30 min—

Countries

India

Contacts

Public ContactDr Yashpal Singh

IMS,BHU

dryashacin1999@gmail.com9918424416

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026