TO EVALUATE THE EFFECT OF NITROGLYCERIN GIVEN BY SUCUTANEOUS INFILTRATION ON RADIAL ARTERY DIAMETER AND FIRST ATTEMPT SUCCESS RATE OF ARTERIAL CANNULATION UNDER ULTRASOUND GUIDANCE METHOD

PROSPECTIVE RANDOMISED STUDY TO EVALUATE THE EFFECT OF SUBCUTANEOUS INFILTRATION OF NITROGLYCERIN ON RADIAL ARTERY DIAMETER AND FIRST ATTEMPT SUCCESS RATE OF ARTERIAL CANNULATION UNDER ULTRASOUND GUIDANCE BY SHORT AXIS CANNULATION METHOD

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/01/039164

Enrollment

214

Registered

2022-01-05

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I169- Hypertensive crisis, unspecified Health Condition 2: I161- Hypertensive emergency Health Condition 3: I211- ST elevation (STEMI) myocardial infarction of inferior wall

Interventions

Intervention1: EVALUATE THE EFFECT OF SUBCUTANEOUS INFILTRATION OF NITROGLYCERIN ON RADIAL ARTERY DIAMETER: NITROGLYCERIN - is a potent vascular smooth muscle relaxant increases the diameter of artery

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are coming are for various surgeries who require hemodynamic monitoring through radial artery cannulation are enrolled in the study.

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. Signs of infection or wound near the puncture site. 3. Recent arterial cannulation at the same site in this hospital. 4. Hemodynamically unstable patients. 5. History or evidence of peripheral vascular disease. 6. Coagulopathies.

Design outcomes

Primary

Measure	Time frame
1.INCREASE IN DIAMETER OF RADIAL ARTERY in mm at the puncture site and the anatomical snuff box after 1 min of infiltration of drug and after 20min at the anatomical snuff box . 2.SUCCESSFUL CANNULATION: Attempt to arterial cannulation by any of the two methods and achieving an end point of free aspiration of blood from the cannula with a syringe through a three way stop cock attached to the cannula. Timepoint: 1.DIAMETER OF RADIAL ARTERY in mm at the puncture site and the anatomical snuff box after 1 min of infiltration of drug and after 20min at the anatomical snuff box. 2.SUCCESSFUL CANNULATION: Attempt to arterial cannulation by any of the two methods and achieving an end point of free aspiration of blood from the cannula with a syringe through a three way stop cock attached to the cannula.	—

Measure

Time frame

1.INCREASE IN DIAMETER OF RADIAL ARTERY in mm at the puncture site and the anatomical snuff box after 1 min of infiltration of drug and after 20min at the anatomical snuff box . 2.SUCCESSFUL CANNULATION: Attempt to arterial cannulation by any of the two methods and achieving an end point of free aspiration of blood from the cannula with a syringe through a three way stop cock attached to the cannula. Timepoint: 1.DIAMETER OF RADIAL ARTERY in mm at the puncture site and the anatomical snuff box after 1 min of infiltration of drug and after 20min at the anatomical snuff box. 2.SUCCESSFUL CANNULATION: Attempt to arterial cannulation by any of the two methods and achieving an end point of free aspiration of blood from the cannula with a syringe through a three way stop cock attached to the cannula.

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Secondary

Measure	Time frame
1. NUMBER OF ATTEMPTS- (ONE ATTEMPT )- From point of skin puncture leadinf to successful cannulation or removal of cannula from the tissue after an unsuccessful attempt . 2. TIME OF INSERTION- Starting from skin puncture to free aspiration of blood from the cannula with a syringe through a three way stop cock attached to the cannula. 3. EFFECT ON ARTERY DIAMETER DISTALLY AFTER CANNULATION- Assessment of radial artery diameter distally over anatomical snuff box after 20 mins of cannulation. Timepoint: 20minutes	—

Measure

Time frame

1. NUMBER OF ATTEMPTS- (ONE ATTEMPT )- From point of skin puncture leadinf to successful cannulation or removal of cannula from the tissue after an unsuccessful attempt . 2. TIME OF INSERTION- Starting from skin puncture to free aspiration of blood from the cannula with a syringe through a three way stop cock attached to the cannula. 3. EFFECT ON ARTERY DIAMETER DISTALLY AFTER CANNULATION- Assessment of radial artery diameter distally over anatomical snuff box after 20 mins of cannulation. Timepoint: 20minutes

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Countries

India

Contacts

Public ContactN K THIRUMALAI PRIYA

SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH

venkymail2014@gmail.com9944731220

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026