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Compare the effect of nebulization of Ketamine and Magnesium sulphate given before operation on the occurrence and degree of sore throat after operation.

Comparison of Pre-operative nebulization with Ketamine and Magnesium Sulphate on the incidence and severity of postoperative sore throat in adult patients undergoing surgery under general endotracheal anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/01/039092
Enrollment
105
Registered
2022-01-03
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J029- Acute pharyngitis, unspecified Health Condition 2: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: ketamine nebulization: PRE-OPERATIVE (only once) NEBULIZATION (for 15mins) WITH KETAMINE (50mg [1ml] ketamine in 4ml saline) ON INCIDENCE AND SEVERITY OF POST-OPERATIVE SORE THROAT IN A

Sponsors

JSS MEDICAL COLLEGE AND HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: -Age 18 ââ?¬â?? 60 years -Either sex -ASA Status I & II -Surgery in supine position under GA for upto or greater than 1 hour

Exclusion criteria

Exclusion criteria: -History of prior sore throat -Patient using steroids or NSAIDS -Patients with Chronic obstructive pulmonary disorder, asthma -Mallampatti Grade greater than II -Patients with greater than 2 attempts of intubation -Pregnant patients -Upper respiratory tract infection -Patients allergic to study drug -Patients requiring Nasogastric tube, throat pack -Oral and nasal surgeries -Patients and his/her legally accepted representatives not willing to provide their voluntary written informed consent for participation in the study

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of nebulized Ketamine , Magnesium sulphate and Normal saline on the incidence and severity of postoperative sore throat in patients undergoing surgeries under general endotracheal anaesthesia.Timepoint: After extubtion to be followed us at 2hrs, 4hrs, 8hrs, 12hrs and 24hours after extubation.—

Secondary

MeasureTime frame
Comparison of postoperative sore throat at 2 hrs, 4 hrs, 8 hrs, 12 hrs and 24 hrs among those receiving Ketamine, Magnesium sulphate and Saline nebulization Timepoint: 2hours after extubation to be followed up at 4hrs, 8hrd, 12hrs and 24hours after extubation—

Countries

India

Contacts

Public ContactDr HEMALATHA S

JSS ACADEMY OF HIGHER EDUCATION AND RESEARCH

shemalatha@jssuni.edu.in9945122585

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026