Comparison of two different methods for guiding intravenous fluid administration during intracranial aneurysmal clipping surgeries

Transthoracic echocardiography based fluid therapy versus central venous pressure guided fluid therapy in patients undergoing intracranial aneurysmal clipping

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/01/039086

Enrollment

Registered

2022-01-03

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery

Interventions

Intervention1: Transthoracic echocardiography: Transthoracic echocardiography based fluid therapy by measurement of Left ventricle outflow tract velocity in patients undergoing intracranial aneurysmal

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients within age group of 18- 65 years who are diagnosed with aneurysmal subarachnoid hemorrhage 2.Require craniotomy for clipping of ruptured intracranial anterior circulation aneurysm under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Patient/relatives refusal 2.Known case of Coronary Artery disease 3.Hunt and Hess grade more than 3. 4.Moderate and severe systolic dysfunction(Ejection Fraction 5.Grade 3 and grade 4 diastolic dysfunction 6.Malignant arrhythmias 7.Valvular heart defects 8.Cardiomyopathies 9.Stunned myocardium due to neurocardiogenic effect of Subarachnoid hemorrhage 10.Patients with end organ dysfunction (hepatic and renal impairment) 11.Poorly controlled hypertension 12.Morbid obesity ( BMI > 35 ) 13.Severe Chronic Obstructive Pulmonary Disease with Cor-pulmonale

Design outcomes

Primary

Measure	Time frame
1. Comparison of total intravenous fluid administered between the groups receiving LVOT-VTI measured by TTE based fluid therapy with CVP guided fluid therapy 2. Differences between number of episodes of hypotension ( MAP 65 mm hg or more than 20% decrease from baseline ) between the groups receiving LVOT-VTI measured by TTE based fluid therapy with CVP guided fluid therapy Timepoint: End of Surgery	—

Measure

Time frame

1. Comparison of total intravenous fluid administered between the groups receiving LVOT-VTI measured by TTE based fluid therapy with CVP guided fluid therapy 2. Differences between number of episodes of hypotension ( MAP 65 mm hg or more than 20% decrease from baseline ) between the groups receiving LVOT-VTI measured by TTE based fluid therapy with CVP guided fluid therapy Timepoint: End of Surgery

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Secondary

Measure	Time frame
Base deficit(mmol/l)Timepoint: Baseline,End of surgery;Extended Glasgow outcome scaleTimepoint: 30 Days;ICU length of stay (days)Timepoint: At time of Discharge from hospital;In hospital mortalityTimepoint: At time of Discharge;Incidence of cerebral vasospasmTimepoint: At time of discharge from ICU;Mean arterial blood pressure (mm hg) Timepoint: 5 Minute Interval;Modified Rankin scaleTimepoint: At Discharge from Hospital;Serum lactate (mmol/lTimepoint: Baseline,End of surgery;Total urine output ( ml) Timepoint: End of Surgery	—

Measure

Time frame

Base deficit(mmol/l)Timepoint: Baseline,End of surgery;Extended Glasgow outcome scaleTimepoint: 30 Days;ICU length of stay (days)Timepoint: At time of Discharge from hospital;In hospital mortalityTimepoint: At time of Discharge;Incidence of cerebral vasospasmTimepoint: At time of discharge from ICU;Mean arterial blood pressure (mm hg) Timepoint: 5 Minute Interval;Modified Rankin scaleTimepoint: At Discharge from Hospital;Serum lactate (mmol/lTimepoint: Baseline,End of surgery;Total urine output ( ml) Timepoint: End of Surgery

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Countries

India

Contacts

Public ContactKARANDEEP SINGH

GB Pant hospital ,New delhi

pganjoo@gmail.com9718599407

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026