Health Condition 1: H408- Other glaucoma
Conditions
Interventions
Control Intervention1: none: nil
Sponsors
ARVO
Eligibility
Inclusion criteria
Inclusion criteria: This will be a pilot study to analyze the aqueous angiographic signals from representative groups of Congenital glaucoma, Juvenile open angle glaucoma and Primary open angle glaucoma patients who will be posted for cataract or trabeculectomy surgery in the routine Operation theatre. Cases: 10 cases each ofCongenital glaucoma, Juvenile open angle glaucoma, Primary open angle glaucoma patientsand controls who will be already posted in the OT for either cataract surgery or filtering glaucoma surgery. The diagnostic criteria for each of the condition will be defined as below: Congenital glaucoma Inclusion criteria for congenital glaucoma will be as follows: untreated/unoperatedcases of congenital glaucoma with enlarged corneal diameters ( >12 mm) who are diagnosed with baseline IOP records of >22 mm Hg detected before 3 years of age and are scheduled for IOP lowering surgery under general anaesthesia. Adult-Onset POAG These will be unrelated POAG patients diagnosed after the age of 40 years presenting with high baseline IOP >25mmHg, scheduled for IOP lowering/ cataract surgery would be included. Only those eyes that had not undergone previous surgery would be included. They will be diagnosed based on open angle on gonioscopy in both eyes, and glaucomatous optic neuropathy in one or both eyes with visual field loss consistent with optic nerve damage. JOAG Patients These will be unrelated POAG patients diagnosed between 10 and 40 years of age presenting with high baseline IOP >25mmHg, scheduled for IOP lowering/ cataract surgery would be included. Only those eyes that had not undergone previous surgery would be included.
Exclusion criteria
Exclusion criteria: Patients excluded from the study: those with a history of steroid use, presence of any other retinal or neurologic pathology, evidence of secondary causes of raised IOP such as pigment dispersion, pseudoexfoliation, or trauma, those with any pathology detected on gonioscopy such as angle recession, pigmentation of the angle greater than grade 3, irido-trabecular contact or peripheral anterior synechiae, and patients with nystagmus will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ·To establish the aqueous outflow patterns in normal healthy subjects undergoing cataract surgery · To ascertain the aqueous outflow patterns in glaucomatous eyes with, congenital glaucoma, juvenile onset high pressure glaucomas, and late onset adult primary open angle glaucomas · To establish phenotypic-functional relationship between the disease severity and the amount of aqueous angiographic signal. Timepoint: It will be assessed at baseline once only as this is a cross sectional study with no follow up required. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To establish phenotypic-functional relationship between the disease severity and the amount of aqueous angiographic signal. 2. to determine the time delay in hagiographic flow in different groups of subjects.Timepoint: It will be assessed at baseline only as this is a cross sectional study with no follow up required. | — |
Countries
India
Contacts
Public ContactSHIKHA GUPTA
Dr. R. P Centre, All India Institute of Medical Sciences
Outcome results
None listed