Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
DR VIJAYA KUMAR MUTHAYALA
Eligibility
Inclusion criteria
Inclusion criteria: 1)Age more than 18 years 2)Admitted with or later developed sepsis due carbapenem resistant organisms 3)Patients who receive 1 or more antibiotics showing invitro activity against carbapenem resistant organisms for at least 48 hours .
Exclusion criteria
Exclusion criteria: 1)Age less than 18 years. 2)Polymicrobial infections comprising carbapenem-susceptible Gram-negative bacteria 3)Unable to follow up for 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical response 1)Improvement in sofa score (if baseline sofa score greater than 3 decrease in score by 30%, if sofa score is less than or equal to 3 decrease by at least 1 point) and 2)Liberation from mechanical ventilation and 3)Stable hemodynamic without vasopressor supportTimepoint: with in 14 days of antibiotic initiation | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiological failure - Is defines as repeat isolation of bacteria phenotypically identical to the index isolateTimepoint: on or after 7 days of antibiotic initiation;Microbiological relapse - Repeat isolation of bacteria phenotypically identical to the index isolate after negative culture to treatmentTimepoint: with in 30 days;MortalityTimepoint: 30 days | — |
Countries
India
Contacts
Public ContactDR RENUKA MK
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION ND RESEARCH
Outcome results
None listed