The study is putting a drug into ones bladder after surgery for Prostate and bladder to reduce the discomfort of catheter placed sfter the procedure and to study symptoms on voiding after the Procedure.

Efficacy of postoperative intravesical bupivacaine administration in reducing catheter related bladder discomfort and postoperative lower urinary tract symptoms in patients following lower urinary tract transurethral electrosurgery â?? A randomized double blinded placebo controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/12/039020

Enrollment

100

Registered

2021-12-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N399- Disorder of urinary system, unspecified Health Condition 2: N398- Other specified disorders of urinary system

Interventions

Intervention1: Intravesical Instillation of Bupivacaine For Bladder Instillation: 40 ml 0.5% Bupivacaine is instilled in the bladder after trans urethral electrosurgery and clamped for 30 minutes. Si

Eligibility

Inclusion criteria

Inclusion criteria: 1.Subjects: All patients (aged >=18 years old) undergoing TURP or TURBT 2.American Society of Anesthesiologist physical status (ASA): I to III

Exclusion criteria

Exclusion criteria: 1.Patients with residual tumor after resection of bladder tumor 2.Bladder perforation 3.Active hematuria 4.Patients exhibiting post operative delirium 5.Patients allergic to Bupivacaine or lidocaine 6.Cardiac conduction with partial or total block 7.Patient with progressive hepatic or renal impairment 8.Patient with class III anti-arrhythmia agent(ex: amiodarone) 9.Patient with acute porphyria 10.Patients on corticosteroid therapy 11.History of substance abuse Uncooperative patients / Refusal to participate

Design outcomes

Primary

Measure	Time frame
To study the efficacy of postoperative intravesical Bupivacaine administration in reducing in Catheter Related Bladder Discomfort in patients undergoing lower urinary tract electrosurgery such as TURP and TURBT.Timepoint: To study the efficacy of postoperative intravesical Bupivacaine administration in reducing in Catheter Related Bladder Discomfort in patients undergoing lower urinary tract electrosurgery such as TURP and TURBT. The CRBD incidence and severity along with LUTS will then be evaluated at 6 hrs, 12 hrs and 24hrs after de-clamping the catheter. Along with that, outcome measures will be assessed at the time of catheter removal.	—

Measure

Time frame

To study the efficacy of postoperative intravesical Bupivacaine administration in reducing in Catheter Related Bladder Discomfort in patients undergoing lower urinary tract electrosurgery such as TURP and TURBT.Timepoint: To study the efficacy of postoperative intravesical Bupivacaine administration in reducing in Catheter Related Bladder Discomfort in patients undergoing lower urinary tract electrosurgery such as TURP and TURBT. The CRBD incidence and severity along with LUTS will then be evaluated at 6 hrs, 12 hrs and 24hrs after de-clamping the catheter. Along with that, outcome measures will be assessed at the time of catheter removal.

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Secondary

Measure	Time frame
To study the effect of postoperative intravesical Bupivacaine administration in reducing the Lower Urinary Tract Symptoms such as dysuria, frequency and urgency, after catheter removal in patients undergoing lower urinary tract electrosurgery such as TURP and TURBT.Timepoint: Patients will be assessed for lower urinary symptoms on day 1 of catheter removal and at 1 week. Assessment is done with Pelvic Pain Urgency Frequency scale and Patient Perception of Bladder Condition scale after catheter remova	—

Measure

Time frame

To study the effect of postoperative intravesical Bupivacaine administration in reducing the Lower Urinary Tract Symptoms such as dysuria, frequency and urgency, after catheter removal in patients undergoing lower urinary tract electrosurgery such as TURP and TURBT.Timepoint: Patients will be assessed for lower urinary symptoms on day 1 of catheter removal and at 1 week. Assessment is done with Pelvic Pain Urgency Frequency scale and Patient Perception of Bladder Condition scale after catheter remova

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Countries

India

Contacts

Public ContactDr Sidhartha Kalra

JIPMER

sid6121984@gmail.com9500674381

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026