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Effect of different doses of Vit. B12 on blood constituents and intestinal bacteria

Investigation of multi- OMIC effects of low and high dose Vit. B12 (methylcobalamin) in volunteers.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/12/039018
Enrollment
60
Registered
2021-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Methylcobalamin: Methylcobalamin 5 mcg /day per oral for upto 12 weeks Control Intervention1: Methylcobalamin: Methylcobalamin 15 mcg /day per oral for upto 12 weeks Control Interventio

Sponsors

KEM Hospital Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Apparently healthy consenting participants Completely COVID-19 vaccinated

Exclusion criteria

Exclusion criteria: Individuals taking / have taken B12 supplements over preceding 3 months. Individuals taking H2 blockers, Proton Pump Inhibitors or those frequently using antacids, Metformin, chronic use of constipation treatment Known patients of Pernicious Anaemia Chronic pancreatitis, pancreatic insufficiency, malabsorption syndrome Patients who have undergone surgical intestinal treatment Pregnant women.

Design outcomes

Primary

MeasureTime frame
Differential abundance of gut microbial communitiesTimepoint: Baseline, 6 weeks, 12 weeks—

Secondary

MeasureTime frame
Circulating levels of vit. B12 (total and HoloTC) and HomocysteineTimepoint: Baseline, 6 weeks, 12 weeks;Different analogues of Vitamin B12 present in the bodyTimepoint: Baseline, 6 weeks, 12 weeks;Differential abundance of metabolites and proteinsTimepoint: Baseline, 6 weeks, 12 weeks—

Countries

India

Contacts

Public ContactDr Chittranjan Yajnik

King Edward Memorial Hospital Research Centre

csyajnik@gmail.com9822847481

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026