To compare the effects of norepinehrine and phenylepherine in preventing the hypotension caused by spinal anaesthesia in caeserean section.

A comparitive study of norepinehrine and phenylepherine for prevention of spinal anaesthesia induced hypotension during caesarean section.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/12/039017

Enrollment

100

Registered

2021-12-29

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 1- Obstetrics

Interventions

Intervention1: Phenylepherine administeration to prevent spinal anaesthesia induced hypotension: Patients will be administered 50ug bolus of phenylepherine followed by infusion of 0.1ug/kg/min phenyle

Eligibility

Inclusion criteria

Inclusion criteria: Females undergoing caesarean section & are ASA grade 1 & 2

Exclusion criteria

Exclusion criteria: a) Cardiac comorbidities(Tachycardia , Valvular Dysfunction) b) Hypertensive disorders of pregnancy c) Peripartum bleeding(APH) d) Body mass index > 40kg/m2 (Obesity) e)Baseline Systolic blood pressure f)Thyroid disordera

Design outcomes

Primary

Measure	Time frame
To evaluate hypotension induced by spinal anaesthesia in norepinephrine group. To evaluate hypotension induced by spinal anaesthesia in phenylepherine group. To compare hypotension in both the groups.Timepoint: SBP and DBP measured from baseline till 5 minutes after delivery of baby.	—

Secondary

Measure	Time frame
Hemodynamic parameters of mother such as maternal bradycardia, intraoperative nausea & vomiting and APGAR scores of neonates at 1 min and 5 min will be noted. Umbilical venous ABG will also be assessed in view of fetal acidosis.Timepoint: Hemodynamic parameters of mother such as maternal bradycardia, intraoperative nausea & vomiting and APGAR scores of neonates at 1 min and 5 min will be noted. Umbilical venous ABG will also be assessed in view of fetal acidosis.	—

Measure

Time frame

Hemodynamic parameters of mother such as maternal bradycardia, intraoperative nausea & vomiting and APGAR scores of neonates at 1 min and 5 min will be noted. Umbilical venous ABG will also be assessed in view of fetal acidosis.Timepoint: Hemodynamic parameters of mother such as maternal bradycardia, intraoperative nausea & vomiting and APGAR scores of neonates at 1 min and 5 min will be noted. Umbilical venous ABG will also be assessed in view of fetal acidosis.

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Countries

India

Contacts

Public ContactDr Kunal Khera

Baba Farid University of Health Sciences

jindalseema77@gmail.com9646050485

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026