Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
Conditions
Interventions
Intervention1: To study the effect of injection dexmedetomidine for sedation in patients on mechanical ventilation in ICU: Patients will receive injecction dexmedetomidine with a bolus of 1micrograms/
Sponsors
Dr Sampurnanand
Eligibility
Inclusion criteria
Inclusion criteria: Post operative patients with need of mechanical ventilation. Â
Exclusion criteria
Exclusion criteria: Patients who are hemodynamically unstable â?? bradycardia (heart rate Patients with neurological disease and active seizures. Patients with acute myocardial ischemia, second and third degree heart block etc. Diabetic patients with uncontrolled blood sugar level. Morbidly obese patients. Patients under 18 years and over 65 years of age. Known allergy to the drug. Pregnancy Patients with chronic liver disease. Patients on chronic opioid therapy or use of alpha 2 agonists or antagonist 24 hours prior to admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary efficacy outcome to be studied is the proportion of the time spent in the target sedation range ( RASS score 0 to -3).Timepoint: 24 hrs | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the hemodynamic responses to administration of Dexmedetomidine and compare them with those of Midazolam. To study the advantage of use of Dexmedetomidine over Midazolam for sedation in the patients if any. To study the effects of Dexmedetomidine and Midazolam on incidence and duration of delirium. To study the adverse effects of Dexmedetomidine if any and compare them with midazolam. Timepoint: 24 hrs | — |
Countries
India
Contacts
Public ContactDr Ajay Kumar Sinha
Govt. Medical College, Haldwani
Outcome results
None listed