Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: Total intravenous anaesthesia combined with fascial plane blocks: TIVA with propofol infusion combined with PEC1 and SAM block
inj fentanyl 1 mcg/kg intravenous.
inj propofol 25-100
Sponsors
nil
Eligibility
Inclusion criteria
Inclusion criteria: 1) Female patients aged 18 to 80 Years 2) ASA physical status 1-3 3) Primary breast cancer without known extension beyond the breast and axillary nodes (i.e. believed to be Tumor Stage 1-3, Nodes 0-2) 4) Scheduled for modified radical mastectomy 5) Wide local excision (lumpectomy) with node dissection 6) Written informed consent
Exclusion criteria
Exclusion criteria: 1) Previous surgery for breast cancer 2) Inflammatory breast cancer 3) Any contraindication to fascial plane blocks (including coagulopathy, allergic to local anaesthetic) 4) Patients with known allergy to eggs or anaesthetic agents (propofol, paracetamol etc.) 5) Patients who have received neoadjuvant chemotherapy prior to surgery 6) Patient not fit for multimodal postoperative therapy (e.g; low ejection fraction) 7) Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Recurrence of breast cancer (loco-regional or distant) 2) Recurrence free survival Timepoint: two years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Postoperative pain (numerical rating scale), total consumption of analgesics and nausea vomiting in first 24 hours after the surgery 2) Chronic post incisional pain at 6 months and 1 year 3) Morbidity and mortality during the two year period. Timepoint: 1) 24 hours 2) 6 months and 1 year 3) 2 years | — |
Countries
India
Contacts
Public ContactDr Sofia Jaswal
Homi Bhabha Cancer Hospital and Research Center, Sangrur and Mullanpur, Punjab
Outcome results
None listed