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Exploring role of pro-inflammatory and anti-inflammatory cytokines in patients with periodontitis

Effect of Non-surgical periodontal therapy on salivary levels of Interleukin-18 and Interleukin-35 in patients with periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/12/038961
Enrollment
92
Registered
2021-12-27
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis Health Condition 2: K053- Chronic periodontitis

Interventions

None listed

Sponsors

Dr Surabhi Durgapal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patient with minimum 20 teeth present. Otherwise healthy non-smoker periodontally healthy and non-smoker with periodontitis patients were recruited. .

Exclusion criteria

Exclusion criteria: Patient with less than 20 no. of teeth present. Pregnant, lactating and menopausal women. Subject who have received periodontal therapy within preceeding 6 months. Patients with diabetes, hypertension and other systemic diseases.

Design outcomes

Primary

MeasureTime frame
To assess and compare the salivary level of Interleukin-18 and Interleukin-35 in subjects with gingivitis, periodontitis and healthy periodontium. Timepoint: Baseline and 3 months—

Secondary

MeasureTime frame
To evaluate the salivary levels of Interleukin-18 and Interleukin-35 before and after the non surgical periodontal therapy in subjects with periodontal disease.Timepoint: Base line and 3 months—

Countries

India

Contacts

Public ContactSurabhi Durgapal

A B Shetty Memorial Institute of Dental Sciences

drmamathasshetty@nitte.edu.in9886756440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026