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A COMPARATIVE STUDY ON THE DOSE REQUIREMENT AND BLOOD FLOW ALTERATONS OF PROPOFOL ADMINISTERED AT DIFFERENT TIME INTERVALS FOLLOWING FENTANYL FOR INDUCTION OF GENERAL ANAESTHESIA IN ADULT PATIENTS IN A TERTIARY CARE HOSPITAL OF KERALA

A COMPARATIVE STUDY ON THE DOSE REQUIREMENT AND HEMODYNAMIC ALTERATIONS OF PROPOFOL ADMINISTERED AT VARYING TIME INTERVALS FOLLOWING FENTANYL FOR INDUCTION OF GENERAL ANAESTHESIA IN ADULT PATIENTS IN A TERTIARY CARE HOSPITAL OF KERALA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/12/038832
Enrollment
45
Registered
2021-12-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: INTRAVENOUS FENTANYL .: FENTANYL 2MCG/KG GIVEN AT 0,3 OR 5 MINUTES BEFORE INDUCTION WITH PROPOFOL . Control Intervention1: INTRAVENOUS PROPOFOL: DOSE REQUIREMENT OF INTRAVENOUS PROPOFOL

Sponsors

PUSHPAGIRI INSTITUTE OF MEDICAL SCIENCE AND RESEARCH CENTRE
Lead Sponsor
DR REJI S VARGHESE
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients between 18-65 years of age 2.Patients undergoing elective surgery under general anesthesia with controlled ventilation. 3.Patients of ASA status 1 and 2.

Exclusion criteria

Exclusion criteria: 1.Patients not giving consent 2.Obesity (BMI > 30Kg/m2) 3.Patients receiving any medications likely to affect Propofol requirement or hemodynamic parameters. 4.History of allergy to eggs and Study drugs 5.Anticipated difficult intubation. 6.Pregnant and lactating women

Design outcomes

Secondary

MeasureTime frame
SECONDARY OUTCOME : PAIN ON PROPOFOL INJECTIONTimepoint: AT 0, 3 AND 5 MINUTES—

Primary

MeasureTime frame
PRIMARY OUTCOME : 1.DOSE REQUIREMENT OF PROPOFOL. 2.HEMODYNAMIC PARAMETERS - HEART RATE , BLOOD PRESSURE . Timepoint: 1.DOSE OF PROPOFOL AT LOSS OF VERBAL RESPONSE . 2.HEART RATE AND BLOOD PRESSURE AT BASELINE , IMMEDIATELY AFTER FENTANYL INJECTION ,IMMEDIATELY AFTER PROPOFOL INDUCTION AND AFTER INTUBATION AND THEREAFTER EVERY 3 MINUTES FOR NEXT 15 MINUTES.—

Countries

India

Contacts

Public ContactKURIAN BABU

PUSHPAGIRI INSTITUTE OF MEDICAL SCIENCES AND RESEARCH CENTRE

drmaryalbert@gmail.com9495685155

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026