Health Condition 1: M179- Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention1: Qurs-e- Mafasil: Two tablets (500 mg each) twice a day orally to be taken with water after meals for 8 weeks
Control Intervention1: Tablet Paracetamol: One tablet (500 mg)twice a day or
Sponsors
Central Council for Research in Unani Medicine CCRUM New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subjects fulfilling ACR clinical criteria for knee OA; andor 2. Subjects having grade II and III Osteoarthritisin knee radiography as perKellegrenLawrence criteria 3. Subjects presenting with/ without the following signs and symptoms: Joint Pain Early morning stiffness Tenderness Swelling Reduced mobility
Exclusion criteria
Exclusion criteria: 1. Subjects having Rheumatoid arthritis, Systemic joint disease or any other type of arthritis 2. Obese Subjects having BMI >30 3. Subjects with uncontrolled Hypertension, Diabetes Mellitus, Tuberculosis, Malignancy, Epilepsy and any other disease requiring long-term treatment 4. Known cases of Renal/ hepatic impairment 5. Patient receiving Intra-articular treatment (e.g., Corticosteroid or Hyaluronic acid) or treatment with medicine for O.A. in previous 3 months (e.g., Glucosamine sulphate, Chondroitin sulphate, Diacerine piascledine) 6. Subjects undergone Arthroscopy or any Knee surgery during last 6 months 7. Pregnancy & lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢ Improvement in clinical sign and symptoms â?¢ Radiological evolution assessed by Joint space narrowing â?¢ Evaluation of pain by visual analog scale (VAS pain) â?¢ Western Ontario MacMaster University Osteoarthritis Index (WOMAC)Timepoint: 8weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Haematological and biochemical assessments for safety Timepoint: 8weeks | — |
Countries
India
Contacts
Public ContactDr Pradeep Kumar
Central Council for Research in Unani Medicine (CCRUM)
Outcome results
None listed