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Measurement of certain vitamin and metal nutrient and an enzyme level; that is; thiamine pyrophosphate, copper and phosphodiestrase; in blood; in individuals having and not having diabetis related eye disease; and comparing them with their vision test report.

Correlation of blood thiamine pyrophosphate, copper, phosphodiesterase and RBC transketolase with clinical visual acuity and diabetic retinopathy grading scores.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/12/038793
Enrollment
104
Registered
2021-12-21
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E113- Type 2 diabetes mellitus with ophthalmic complications

Interventions

None listed

Sponsors

PG grant KMC Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group A) individuals 40-75yrs age and both genders; without having diabetes mellitus. Group B) individuals 40-75yrs age and both genders, diagnosed with diabetes mellitus and havenâ??t developed any retinal complication. Group C) individuals 40-75yrs age and both genders, with diabetes mellitus and diagnosed with non proliferative diabetic retinopathy. Group D) individuals 40-75yrs age and both genders, with diabetes mellitus and diagnosed with proliferative diabetic retinopathy.

Exclusion criteria

Exclusion criteria: i. individuals with other retinal conditions ii. individuals undergone recent surgery or recent blood transfusion ( iii. individuals having other comorbid diseases like malignancies, severe systemic illness iv. chronic alcoholics v. anaemic patients

Design outcomes

Primary

MeasureTime frame
Serum thiamine pyrophosphate, copper, phosphodiesterase (PDE) among all the participants.Timepoint: baseline—

Secondary

MeasureTime frame
Visual acuity scores and diabetic retinopathy grading as per the modified ETDRS criteria among patients with DRTimepoint: baseline and 3 months (post LASER / anti VEGEF treatment among those patients with retinopathy undergoing treatment).—

Countries

India

Contacts

Public ContactDr Anitha P Rao

Dept of Biochemistry, KMC Manipal, MAHE.

krishnananda.prabhu@manipal.edu9844380157

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026