Comparative evaluation of antibacterial efficacy of Solanum Xanthocarpum induced with Silver Nanoparticles as an Intracanal medicament in patients with apical periodontitis-A Randomised clinical Trial-A pilot study

Comparative evaluation of antibacterial efficacy of Solanum Xanthocarpum induced with Silver Nanoparticles as an Intracanal medicament in patients with apical periodontitis-A Randomised Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/12/038763

Enrollment

Registered

2021-12-20

Start date

Unknown

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Solanum xanthocarpum with silver Nanoparticles as an Intracanal medicament: 0.01% of solanum xanthocarpum fruit extract with silver nanoparticle gel is delivered by means of syringe in

Eligibility

Inclusion criteria

Inclusion criteria: NECROTIC TEETH WITH APICAL PERIODONTITIS , TEETH WITH FAVOURABLE ROOT MORPHOLOGY,TEETH WITH CLOSED APEX

Exclusion criteria

Exclusion criteria: TEETH WITH OPEN APEX , PATIENTS WITH RECENT TRUAMA , VITAL TEETH , UN FAVOURABLE ROOT MORPHOLOGY ,MEDICALLY COMPROMISED PATIENTS ,TEETH WITH EXTERNAL /INTERNAL ROOT RESORPTION,PERIODONTALLY COMPROMISED TEETH LIKE MOBILE TEETH AND TEETH WITH EXCESSIVE BONE LOSS, CRACKED TOOTH

Design outcomes

Primary

Measure	Time frame
microbial load count using RT-PCRTimepoint: S1 sample is collected from the root canal with a paper point after access opening is done ,S2 is collected after cleaning and shaping ,S3 is collected one week after placement of Intracanal medicament	—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactSwathi Udayabhanu

Saveetha Dental College

sindhuramesh@saveetha.com9840136543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026