Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Tofacitinib: Tofacitinib 10 mg BD PO for 14days
Control Intervention1: NIL: NIL
Sponsors
Bangalore Medical College and Research Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1. SARS Co V2 positivity to the nasal swab by RTPCR 2. Presence of radiological findings of pneumonia assessed by chest radiography and HRCT 3. Patients with eGFR 15-30 ml/min 4. PaO2/ FiO2 100-300 mmHg at ABG
Exclusion criteria
Exclusion criteria: 1. Patients with active / latent tuberculosis 2. Patients with pre - existing AKI, EGFR 3. Patients with deranged liver function test 4. Patients with history of chronic dialysis and renal transplant 5. Patients with history of thrombophlebitis and acute / chronic autoimmune disorder 6. Patients with serology positive 7. Patients on immunosuppressive drugs 8. Pregnant and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Incidence and duration of non-invasive ventilation/ high flow oxygen 2. Incidence and duration of invasive mechanical ventilation 3. Frequency of adverse kidney events 4. Number of days in ICU 5. ICU mortality 6. Hospital mortalityTimepoint: NEWS score baseline, and at 1week, 2 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of adverse kidney eventsTimepoint: at 1 week and 2 weeks | — |
Countries
India
Contacts
Public ContactDr Vijay Kumar H N
Bangalore Medical College and Research Institute
Outcome results
None listed