Skip to content

Mechanism and Impact of intestinal disturbances on brain function

Gut-Brain Axis in Pediatric Population

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/12/038638
Enrollment
90
Registered
2021-12-15
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A09- Infectious gastroenteritis and colitis, unspecified

Interventions

Control Intervention1: Electroencephalography (EEG): It is the measurement of electrical activity in different parts of the brain and the recording of such activity as a visual trace. This interventi

Sponsors

Dr Varnit Shanker
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria 1. Age 2. Complete medical records of admitted patients (Patient demographics, Consent to retrieve medical records, history of presenting complaints, antenatal history, past significant history, immunization history, treatment history, lab investigations - CBC, CRP, S. IL6 levels, S. GFAP level, Stool examination for rotaviral antigen, Stool Culture for aerobic and fungal pathogens and EEG) 3. Date of admission on or after July 1, 2021 4. Cases should be able to be classified into one of three categories - a. Only Gastrointestinal complaints of Infectious etiology with stool positive for rotavirus antigen or positive stool culture for E coli (VTEC) or Shigella species. b. Only Neurological conditions including but not limited to CNS infections, Uncontrolled Seizures, genetic epilepsy, head injury, encephalopathies, CNS autoimmune pathology such as Autoimmune encephalitis, Intra cranial hemorrhage, etc. c. Non-gastrointestinal and non-Neurological conditions group including conditions such as pneumonia, tuberculosis, measles, dengue, malaria, enteric fever, etc.

Exclusion criteria

Exclusion criteria: 1. Congenital malformations including Heart Malformations 2. Syndromic presentations 3. History of surgical intervention 4. Recurrent hospitalizations ( > 2 times/year) 5. On Oral/IV Antibiotics for more than 7 days before hospitalization 6. On Oral/IV steroids before hospitalization 7. Cases of Burns or Road traffic accidents 8. ICU stay > 12 days 9. Discharged against medical advise 10. Feeding difficulties

Design outcomes

Primary

MeasureTime frame
Significant differences in the EEG amplitude of patients with neurological conditions and those without neurological conditions.Timepoint: 24 hours

Secondary

MeasureTime frame
Significant differences in the serum GFAP of patients with neurological conditions and those without neurological conditions.Timepoint: 72 hours

Countries

India

Contacts

Public ContactVarnit Shanker

DACH Jaipur

atul_shanker@hotmail.com9828012719

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026