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A clinical trial to study effects of clopidogrel and newer antiplatelet agents ( Ticagrelor and Prasugrel) in patients with acute coronary syndrome who underwent PCI.

Safety and efficacy of switching the antiplatelet regimen in patients from newer more potent P2Y2 inhibitors to clopidogrel at 1 month post PCI

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/12/038560
Enrollment
200
Registered
2021-12-10
Start date
Unknown
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I249- Acute ischemic heart disease, unspecified

Interventions

Intervention1: Clopidogrel: 75mg OD for 23 months for intervention group Control Intervention1: Prasugrel: 10 mg OD for 1 month for intervention group and 2 years for comparator group Control Interven

Sponsors

U N Mehta institute of cardiology and research center
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ACS requiring early percutaneous coronary intervention PCI within 72 h treatment with aspirin and a newer P2Y12 blocker at discharge, no major adverse event one month after the ACS and age greater than 18 years

Exclusion criteria

Exclusion criteria: history of intracranial bleeding, contraindication to use of aspirin, clopidogrel, prasugrel, or ticagrelor; major adverse event

Design outcomes

Primary

MeasureTime frame
composite of cardiovascular death, unplanned hospitalization leading to urgent coronary revascularization, and bleeding episodes as defined by the BARC classification_ 2 at 1 year after ACS.Timepoint: 1 year—

Secondary

MeasureTime frame
composite of cardiovascular death, unplanned hospitalization leading to urgent coronary revascularization, and bleeding episodes as defined by the BARC classification_ 2 atTimepoint: at 6 months—

Countries

India

Contacts

Public ContactDr Pooja Vyas

U.N.Mehta institute of cardiology and research center

poojavyaskothari@gmail.com09925004922

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026