Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services
Conditions
Interventions
Intervention1: Methylene blue: Methylene blue (MB) is a reduction agent traditionally used in the treatment of methemoglobinaemia, however, it has been increasingly used in the management of refractor
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: Patients older than 18 years diagnosed with septic shock during their ICU stay whose relatives give informed consent for the study will be considered for enrolment. Within 24hrs of septic shock
Exclusion criteria
Exclusion criteria: Patients whose relatives refuse to give consent for the study. Unstable coronary artery syndrome (acute myocardial infarction during this episode of shock based on the combination of history, electrocardiogram and enzyme changes) or underlying cardiac dysfunction [cardiac index (CI) Stroke or head injury. Chronic renal failure on maintenance dialysis. Malignancy or other irreversible disease or condition for which mortality was estimated to be very high (defined by investigator), Acute mesenteric ischemia either proven or suspected Raynaudâ??s phenomenon Pregnancy Organ transplantation. Known hypersensitivity to norepinephrine or methylene blue -G 6PD deficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the dose of Norepinephrine required to achieve target MAP(65-70mm of Hg) after 6,12 and 24 hours of starting the infusion.Timepoint: To study the dose of Norepinephrine required to achieve target MAP(65-70mm of Hg) after 6,12 and 24 hours of starting the infusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of vasopressor requirement. Changes in lactate level at 6,12 and 24 hours after starting the infusion. Urine output in ml per hour at 6,12 and 24 hours after starting of infusion. Mortality during the ICU stay after starting Methylene blue or Vasopressin. Changes in the Sequential Organ Failure Assessment (SOFA) score after 6,12 and 24 hours of starting vasopressor infusion.Timepoint: Duration of vasopressor requirement. Changes in lactate level at 6,12 and 24 hours after starting the infusion. Urine output in ml per hour at 6,12 and 24 hours after starting of infusion. Mortality during the ICU stay after starting Methylene blue or Vasopressin. Changes in the Sequential Organ Failure Assessment (SOFA) score after 6,12 and 24 hours of starting vasopressor infusion. | — |
Countries
India
Contacts
Public ContactHarshavardhan R KURI
AIIMS JODHPUR
Outcome results
None listed