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Transcranial Doppler guided management of severe traumatic brain injury in trauma intensive care unit

Transcranial Doppler-Guided Management Of Severe Traumatic Brain Injury Admitted In Trauma Intensive Care Unit: A Prospective, Randomized Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/12/038456
Enrollment
80
Registered
2021-12-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S060- Concussion Health Condition 2: S062- Diffuse traumatic brain injury Health Condition 3: S064- Epidural hemorrhage Health Condition 4: S063- Focal traumatic brain injury Health Condition 5: S068- Other specified intracranial injuries Health Condition 6: S061- Traumatic cerebral edema Health Condition 7: S066- Traumatic subarachnoid hemorrhage Health Condition 8: S065- Traumatic subdural hemorrhage Health Condition 9: S069- Unspecified intracranial injury

Interventions

Intervention1: transcranial doppler: ICU management of patients in initial 72 hours will be guided by Transcranial doppler measured parameters in addition to clinical and radiological examination Cont

Sponsors

PGIMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients 18-65 years of age, with severe TBI (Glasgow Coma Scale 3-8) 25 at the time of admission to Intensive Care Unit 2.Admitted to Trauma Intensive Care Unit (ICU) for mechanical ventilatory support and conservative management. 3.Admitted to Trauma ICU within 48 hours of injury

Exclusion criteria

Exclusion criteria: 1. Pregnant females and pediatric patients 2. Relatives unwilling to give consent for participation in the study 3. Patients admitted to hospital >24 of injury 4. Glasgow Coma Scale (GCS) of 3 with bilateral fixed and dilated pupils 5. Non-survivable injury like decapitation or hemicorporectomy. • Inability to obtain ultrasound window for performing Transcranial doppler (TCD)

Design outcomes

Primary

MeasureTime frame
Functional status and orientation at 3 months following injury, assessed with the use of the Extended Glasgow Outcome Scale [GOS-E](annexure I) and the Disability Rating Scale [DRS](annexure II).Timepoint: 3 months post injury—

Secondary

MeasureTime frame
. Total ventilator daysTimepoint: end of icu stay;Adverse events/complications, if anyTimepoint: end of icu stay;Brain-specific treatments receivedTimepoint: end of icu stay;Frequency of neurosurgical proceduresTimepoint: end of icu stay;GCS at the end of hospital stayTimepoint: end of hospital stay;Incidence of neurological worseningTimepoint: end of icu stay;Time to hospital dischargeTimepoint: end of hospital stay;Total length of ICU stayTimepoint: end of icu stay—

Countries

India

Contacts

Public ContactNidhi Bhatia

Post Graduate Institute of Medical Education and Research

nidhi.bhatia75@gmail.com7087008483

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026